N,N-Dimethyltryptamine

Background

  • Also known as DMT
  • Serotonergic hallucinogen
  • Naturally occurring in several plant species
  • Usually smoked, less frequently combined with MAOI and ingested orally
  • Produces rapid onset, short, but extremely intense trip

Clinical Features

  • Onset within 2m, effects last ~20-60m
  • Notorious for producing intense, intricate psychedelic experiences
    • Dissociation, sensory enhancement/distortions, visual hallucinations
    • Paranoia, fear/anxiety
  • Adrenergic stimulation: mydriasis, mild tachycardia, mild hypertension, hyperthermia
  • Nausea/vomiting
  • Seizure (rare)

Differential Diagnosis

Hallucinogens

Dissociative drugs

Evaluation

  • Not detected on drug screens
  • Evaluate for other organic causes of hallucinations or hyperadrenergic symptoms
  • Evaluate for co-ingestions

Management

  • Supportive care

Disposition

See Also

External Links

References