25C-NBOMe

Although this article specifically addresses 25C-NBOMe, there are also 25I- and 25B- versions of the compound

Background

  • 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
  • Other names: NBOMe-2C-C, Boom, C-Boom, Cimbi-82, Pandora, N-bomb, Holland film, Dime
  • Potent partial agonist of 5-HT2A receptor[1]
  • First synthesized in Germany by Ralf Heim in 2004[2]
  • Member of new class of toxic phenethylamine derivatives (NBOMe) with similar effects to LSD
  • Commonly ingested orally or sublingually; can also be taken nasally, parenterally, vaginally, rectally.
  • Dose of 50-200 micrograms causes hallucinogenic effects[1]
  • Onset 0-15 mins, peak 30-90 mins, total duration 4-10 hours[1]
  • Case reports of ingestions have included overdose symptoms of grand mal seizures and purpuric rash and mydriasis with 25B-NBOMe variant[3]
  • The 25I- version of the drug has symptoms described as tachycardia, hallucinations, hypertension, and seizures and agitation.[4]
25C-NBOMe

Clinical Features

Evaluation

Management

Disposition

  • Admit for monitoring on all patients with continuing agitation requiring escalating doses of sedation
  • Consider discharge if complete resolution of symptoms

See Also

References

  1. 1.0 1.1 1.2 Bersani FS, Corazza O, Albano G, et al. 25C-NBOMe: preliminary data on pharmacology, psychoactive effects, and toxicity of a new potent and dangerous hallucinogenic drug. Biomed Res Int. 2014;2014:734749.
  2. Heim R. “Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur”. :Entwicklung eines neuen Struktur-Wirkungskonzepts. Berlin, Freie University, Dissertation, 2003
  3. Poklis JL. et al. Determination of 4 bromo 2,5 dimethoxy N [2 methoxyphenyl) methyl] benzeneethanamine (25B-NBOMe) in serum and urine by high performance liquid chromatography with tandem mass spectrometry in a case of severe intoxication. Drug Test Anal. 2004;6:764-9
  4. Poklis J. Devers KG et al. Postmortem detection of 25I-NBOMe [2-(4-iodo-2,5-dimethoxyphenyl)methyl] ethanamine] in fluids and tissues determined by high performance liquid chromatography with tandem mass spectrometry from a traumatic death. Forensic Sci Int. 2014;234:e14-e20
  5. Boyer EW, Shannon M. The serotonin syndrome. NEJM. 2005;352:1112-20