Valacyclovir

General

  • Type: Antiviral, inhibits DNA polymerase
  • Dosage Forms: 500, 1000
  • Common Trade Names: Valtrex

Adult Dosing

HSV-1

  • Acute episode: 2000mg PO BID x 1 day
  • Suppression: 500mg PO Qday

Genital HSV

  • 1st episode: 1000mg PO BID x 7-10 days, start within 48-72 hour of symptoms
  • recurrence: 500mg PO BID x 3 days, alternative: 1000mg PO qday x 5 days

Shingles

  • 1000mg PO TID x 7 days

Pediatric Dosing

Genital HSV

  • ≥12 yrs same as adult dosing for adolescents

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

References