Methyl isocyanate

Background

  • Compound that is intermediate chemical in formulation of many carbamate pesticides
  • Highly toxic if inhaled, contacted, or ingested
  • Odorless, clear liquid
  • Principle toxicant in Bhopal disaster

Clinical Features

  • Potent lachrymal agent
  • Symptom onset may be immediate after exposure or delayed 1-2 days
  • Mucosal irritation of eyes, nose, pharynx, skin
  • Cough, chest pain, SOB
  • At high levels: pulmonary edema, severe reactive airway disease, bronchial/alveolar hemorrhage

Differential Diagnosis

Chemical weapons

Evaluation

  • Clinical diagnosis, evaluate for alternatives and complications

Management

  • Decontaminate
  • Supportive

Disposition

See Also

External Links

References

Authors:

Claire