Methotrexate

Administration

  • Type: Immunosuppressant/antineoplastic
  • Dosage Forms:
  • Routes of Administration: IV/IM, oral
  • Common Trade Names:

Adult Dosing

Ectopic pregnancy

  • Single-dose regimen: Methotrexate 50 mg/m2

Pediatric Dosing

Special Populations

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug
  • Breastfeeding, pregnant, or possibility of impregnating someone
  • Blood dyscrasias
  • Chronic liver disease

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 8-15hr
  • Metabolism: Extensive hepatic and intracellular
  • Excretion: Mostly renal. Dialyzable.

Mechanism of Action

  • Inhibits dihydrofolate reductase→ blocks DNA synthesis and thus, cellular replication/repair

Comments

See Also

Methotrexate_toxicity

References