Pancytopenia

Background

Clinical Features

  • Signs/symptoms of anemia (e.g. fatigue, dyspnea, tachycardia, pallor)
  • Signs/symptoms of thrombocytopenia (e.g. petechiae/purpura, mucosal bleeding, GI bleed, hematuria, intracranial hemorrhage)
  • Signs/symptoms of leukopenia (e.g. recurrent, severe, or opportunistic infection)

Differential Diagnosis

Pancytopenia Causes

Evaluation

  • CBC Findings: Low hemoglobin/hematocrit, platelets, and white blood cell count

Aditional Considerations

  • Evaluate for causes of pancytopenia
    • Drug history, infectious work-up, smear, malignancy work-up
  • Evaluate for dangerous sequalae

Management

Disposition

See Also

External Links

References