Fever of unknown origin (peds): Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
* | *Original definition<ref name="Kaya">Kaya A, Ergul N, Kaya SY, et al. The management and the diagnosis of fever of unknown origin. Expert Rev Anti Infect Ther. 2013 Aug;11(8):805-15.</ref> | ||
**Fever >38.3 C on several occasions | |||
**Lasting for at least 3 weeks | |||
**No clear diagnosis after 1 week inpatient workup | |||
*Newer definition<ref>Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35-51.</ref> - "Prolonged fever" with: | |||
**3 outpatient visits without identifying a cause '''or''' | |||
**3 inpatient days without identifying a cause '''or''' | |||
**1 week of “intelligent and invasive” ambulatory investigation | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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==References== | ==References== | ||
<References/> | |||
[[Category:Peds]] | [[Category:Peds]] | ||
Revision as of 05:55, 10 August 2015
Background
Clinical Features
- Original definition[1]
- Fever >38.3 C on several occasions
- Lasting for at least 3 weeks
- No clear diagnosis after 1 week inpatient workup
- Newer definition[2] - "Prolonged fever" with:
- 3 outpatient visits without identifying a cause or
- 3 inpatient days without identifying a cause or
- 1 week of “intelligent and invasive” ambulatory investigation
Differential Diagnosis
- INFECTION
- Bacterial
- Adenitis
- Endocarditis
- Mastoiditis
- Occult abscess
- Pyelonephritis
- Sinusitis
- Tb
- Viral
- CMV
- Hep A,B, C
- Mono
- Chlamydial
- Lymphogranuloma venereum
- Psittacosis
- Mycoplasmal
- Fungal
- Blastomycosis
- Cysticercosis
- Histoplasmosis
- Rickettsial
- Q fever
- Rocky Mt
- Parasitic
- Malaria
- Toxo
- Bacterial
- COLLAGEN VASCULAR
- JRA
- LSE
- Regional enteritis
- Rheumatic fever
- Ulcerative colitis
- Vasculitis
- MALIGNANCY
- Leukemia
- Lymphoma
- Neuroblastoma
- Wilm's tumor
- DRUG INDUCED
- Antibiotics
- Anticonvulsants
- Anti TB
- Procainamide
- Quinidine
- Serum sickness
- MISC
- AIDS
- CNS
- Environmental
- Factitious
- Familial dysautonomia
- Kawasaki
- PE
- Serial infections
- Thyrotoxicosis
Diagnosis
- Clinical (preliminary) diagnosis
Management
Disposition
- Frequently admitted for workup