Fever of unknown origin (peds)
- Prolonged fever of unknown origin without identified cause generally has favorable prognosis.
- Original definition
- Fever >38.3 C on several occasions
- Lasting for at least 3 weeks
- No clear diagnosis after 1 week inpatient workup
- Newer definition - "Prolonged fever" with:
- 3 outpatient visits without identifying a cause or
- 3 inpatient days without identifying a cause or
- 1 week of “intelligent and invasive” ambulatory investigation
- Non-infectious Inflammatory
- Regional enteritis
- Rheumatic fever
- Ulcerative colitis
- Wilm's tumor
- Drug Induced
- Anti TB
- Serum sickness
- Clinical (preliminary) diagnosis
- Treat underlying cause (once identified)
- Empiric treatment generally not recommended
- Frequently admitted for workup
- Kaya A, Ergul N, Kaya SY, et al. The management and the diagnosis of fever of unknown origin. Expert Rev Anti Infect Ther. 2013 Aug;11(8):805-15.
- Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35-51.