Hypercalcemia of malignancy: Difference between revisions

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==Background==
==Background==
#Causes:
===Causes===
##PTHrP release
#PTHrP release
###SCC (particularly of the head and neck), breast renal, endometrial cancer
##SCC (particularly of the head and neck), breast renal, endometrial cancer
##Local osteolysis
#Local osteolysis
###Associated primarily with bone mets
##Associated primarily with bone mets
###Multiple myeloma, lung, breast cancer
##Multiple myeloma, lung, breast cancer
##Production of vitamin D analogues
#Production of vitamin D analogues
###Lymphoma (Hodgkin)
##[[Lymphoma]] (Hodgkin)


==Clinical Features==
==Clinical Features==

Revision as of 04:26, 25 June 2015

Background

Causes

  1. PTHrP release
    1. SCC (particularly of the head and neck), breast renal, endometrial cancer
  2. Local osteolysis
    1. Associated primarily with bone mets
    2. Multiple myeloma, lung, breast cancer
  3. Production of vitamin D analogues
    1. Lymphoma (Hodgkin)

Clinical Features

  1. See Hypercalcemia

Differential Diagnosis

Causes of Hypercalcemia

Oncologic Emergencies

Related to Local Tumor Effects

Related to Biochemical Derangement

Related to Hematologic Derangement

Related to Therapy

Diagnosis

  1. Chem10
  2. Ionized Ca
  3. CBC
  4. LFTs (alk phos, albumin)
  5. ECG

Treatment

  1. See Hypercalcemia

Disposition

  1. Ca <12
    1. Home with f/u if oncology concurs
  2. Ca>12
    1. Admit ward
  3. ECG changes
    1. Admit telemetry

See Also

References