Lithium

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Administration

  • Type:
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names:

Adult Dosing

  • Maintenance: 300mg PO 3 to 4 times daily; desired serum lithium level 0.6 to 1.2 mEq/L
  • Acute manic episode: 600mg PO 3 times daily; desired serum lithium level 1 to 1.5 mEq/L

Pediatric Dosing

Safety/efficacy not established in children <12yo

Special Populations

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug
  • Dehydration, cardiovascular disease, sodium depletion, concurrent diuretics, renal disease: needs inpatient monitoring if treatment required

Adverse Reactions

Serious

  • Toxicity (see Lithium toxicity)
  • Seizure, ataxia, raised ICP
  • Angioedema
  • Erythema multiforme

Common

  • Hypothroidism, weight gain
  • Nephrotoxicity
  • Fine tremor, hyperreflexia
  • Leukocytosis
  • Nausea, gastritis
  • Acne


Pharmacology

  • Half-life: 14-50hr
  • Metabolism: Renal
  • Excretion: Renal

Mechanism of Action

Comments

See Also

References