CMV colitis: Difference between revisions
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==Background== | ==Background== | ||
*CMV is part of the Herpesviridae family | *CMV is part of the Herpesviridae family | ||
*50-80% of the world's population is seropositive for CMV | *50-80% of the world's population is seropositive for CMV | ||
*Causes a mild or undetectable infection in immunocompetent hosts | *Causes a mild or undetectable infection in immunocompetent hosts | ||
*Severe systemic illness is found in immunosuppressed hosts | *Severe systemic illness is found in immunosuppressed hosts | ||
==Clinical Features== | ==Clinical Features== | ||
*[[Fever]] | |||
*[[Special:MyLanguage/Fever|Fever]] | |||
*Anorexia | *Anorexia | ||
*Malaise | *Malaise | ||
*[[Abdominal pain]], Abdominal distention, [[constipation]] | *[[Special:MyLanguage/Abdominal pain|Abdominal pain]], Abdominal distention, [[Special:MyLanguage/constipation|constipation]] | ||
*[[Nausea/vomiting]] | *[[Special:MyLanguage/Nausea/vomiting|Nausea/vomiting]] | ||
*Chronic watery [[diarrhea]] | *Chronic watery [[Special:MyLanguage/diarrhea|diarrhea]] | ||
*[[rectal bleeding|Bloody diarrhea]] | *[[Special:MyLanguage/rectal bleeding|Bloody diarrhea]] | ||
*Worsening symptoms of [[inflammatory bowel disease]] | *Worsening symptoms of [[Special:MyLanguage/inflammatory bowel disease|inflammatory bowel disease]] | ||
*Weight loss | *Weight loss | ||
*[[Dehydration]] | *[[Special:MyLanguage/Dehydration|Dehydration]] | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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{{Colitis DDX}} | {{Colitis DDX}} | ||
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{{CMV types}} | {{CMV types}} | ||
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==Evaluation== | ==Evaluation== | ||
==Management== | ==Management== | ||
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{{CMV colitis treatment}} | {{CMV colitis treatment}} | ||
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==Disposition== | ==Disposition== | ||
==See Also== | ==See Also== | ||
*[[Cytomegalovirus (CMV) infection]] | |||
*[[Special:MyLanguage/Cytomegalovirus (CMV) infection|Cytomegalovirus (CMV) infection]] | |||
==External Links== | ==External Links== | ||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:ID]] [[Category:GI]] | [[Category:ID]] [[Category:GI]] | ||
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Latest revision as of 21:54, 4 January 2026
Background
- CMV is part of the Herpesviridae family
- 50-80% of the world's population is seropositive for CMV
- Causes a mild or undetectable infection in immunocompetent hosts
- Severe systemic illness is found in immunosuppressed hosts
Clinical Features
- Fever
- Anorexia
- Malaise
- Abdominal pain, Abdominal distention, constipation
- Nausea/vomiting
- Chronic watery diarrhea
- Bloody diarrhea
- Worsening symptoms of inflammatory bowel disease
- Weight loss
- Dehydration
Differential Diagnosis
Colitis
- Viral gastroenteritis
- Bacterial gastroenteritis
- Campylobacter infections
- Clostridium difficile colitis
- Colon cancer
- Crohn disease
- Cryptosporidiosis
- Mycobacterium Avium-Intracellulare
- Toxic megacolon
- Ulcerative colitis
- Ischemic bowel disease (e.g. mesenteric ischemia, strangulated hernia)
- Pseudomembranous enterocolitis
- Lymphoma
- Ileocecal amebiasis
- Sarcoidosis
- Yersinia
- Campylobacter
CMV Diseases
Evaluation
Management
- Ganciclovir 5mg/kg IV q12hrs x 21 days (or until resolution of symptoms)
- Foscarnet 90mg/kg IV q12hrs daily x 21 days (or until resolution of symptoms)
Disposition
See Also