P450

Background

Coumadin

Antimicrobials

Avoid /P450 Inhibitors

Use

SignificantP450 Inhibitors in General

  • Grapefruit juice
  • Valproate
  • INH
  • Protease inhibitors (-navir, i.e. ritonavir)
  • SSRIs, except escitalopram
  • Amiodarone
  • Fluoroquinolones
  • Sulfonamides
  • Macrolides
  • Cimetidine
  • Omeprazole
  • Ketoconazole
  • Acute EtOH

SignificantP450 Inducers in General

  • Phenytoin
  • Carbamazepine
  • Ethosuximide
  • Quinidine/quinine
  • Rifampin
  • Griseofulvin
  • Glucocorticoids
  • Barbituates
  • St. John's wort
  • Chronic EtOH
  • Tobacco smoking