Crashing pediatric patient? Check out the critical care quick reference section for drug dosing and equipment sizes. Available on both WikEM's website and app.
P450
From WikEM
Contents
Background
Antimicrobials
Avoid /P450 Inhibitors
- Quinolones, especially levofloxacin
- Macrolides, especially erythromycin
- Bactrim and sulfonamides
- Flagyl
- Nafcillin, oxacillin
Use
SignificantP450 Inhibitors in General
- Grapefruit juice
- Valproate
- INH
- Protease inhibitors (-navir, i.e. ritonavir)
- SSRIs, except escitalopram
- Amiodarone
- Fluoroquinolones
- Sulfonamides
- Macrolides
- Cimetidine
- Omeprazole
- Ketoconazole
- Acute EtOH
SignificantP450 Inducers in General
- Phenytoin
- Carbamazepine
- Ethosuximide
- Quinidine/quinine
- Rifampin
- Griseofulvin
- Glucocorticoids
- Barbituates
- St. John's wort
- Chronic EtOH
- Tobacco smoking
