Griseofulvin

Administration

  • Type: Antifungal
  • Dosage Forms: Suspension 125mg/5ml; Tablet 125mg, 250mg, 500mg
  • Routes of Administration: Oral
  • Common Trade Names: Grifulvin V, Gris-PEG

Adult Dosing

  • 250-1000mg PO daily

Pediatric Dosing

  • 13.6-22.7kg: 125-250mg PO daily
  • >22.7kg: 250-500mg PO daily

Special Populations

Contraindications

  • Allergy to class/drug
  • Hepatocellular failure
  • Porphyria
  • Pregnancy

Adverse Reactions

Serious

  • Acroparesthesia

Common

  • Photosensitivity, rash, urticaria
  • Nausea/vomiting, diarrhea
  • Headache

Pharmacology

  • Half-life: 9-22h
  • Metabolism: Liver
  • Excretion: Urine, feces, perspiration

Mechanism of Action

  • Fungistatic, deposits into keratin precursor cells and inhibits fungal mitosis

Comments

See Also

References

Authors:

Claire