IgA nephropathy

Background

  • Nephritic syndrome, form of chronic glomerulonephritis caused by deposition of IgA immune complexes in glomeruli
  • Slowly progressive

Clinical Features

  • Hematuria, persistent or recurrent, macroscopic or asymptomatic microscopic
    • Gross hematuria initially begins a few days after febrile illness, thus mimicking acute postinfectious glomerulonephritis
  • Mild proteinuria
  • +/- flank pain, fever during acute episodes
  • Usually slowly progressive, but rapidly progressive glomerulonephritis manifests initially in <10% of patients

Differential Diagnosis

Hematuria


Evaluation

  • UA
    • Hematuria, usually with dysmorphic RBCs, occasional RBC casts
    • Mild proteinuria
  • BMP
    • Creatinine usually normal unless progressed
  • Definitive diagnosis with renal biopsy

Management

Disposition

Discharge

See Also

External Links

References

https://www.merckmanuals.com/professional/genitourinary-disorders/glomerular-disorders/immunoglobulin-a-nephropathy

Authors:

Claire