Angiotensin II receptor antagonists

(Redirected from ARB)

Background

  • Also known as angiotensin receptor blockers (ARBs), AT1-receptor antagonists or sartans
  • A group of pharmaceuticals that modulate the renin–angiotensin system, they block activation of angiotensin II AT1 receptors, thus preventing angiotensin II from binding
  • Main uses are in the treatment of hypertension, diabetic nephropathy and congestive heart failure

Medications

Drug Trade Name Biological half-life [h] Protein binding [%] Bioavailability [%] Renal/hepatic clearance [%] Food effect Daily dosage [mg]
Losartan Cozaar 6-9 h 98.7% 33% 10%/90% Minimal 50–100 mg
EXP 3174 6–9 h 99.8% 50%/50%
Candesartan Atacand 9h >99% 15% 60%/40% No 4–32 mg
Valsartan Diovan 6 h 95% 25% 30%/70% No 80–320 mg
Irbesartan Avapro 11–15 h 90–95% 70% 1%/99% No 150–300 mg
Telmisartan Micardis 24 h >99% 42–58% 1%/99% No 40–80 mg
Eprosartan Teveten 5 h 98% 13% 30%/70% No 400–800 mg
Olmesartan Benicar/Olmetec 14–16 h >99% 29% 40%/60% No 10–40 mg
Azilsartan Edarbi 11 h >99% 60% 55%/42% No 40–80 mg
Fimasartan Kanarb 7-11 h >97% 30-40% - - 30–120 mg

See Also

Authors:

Ross Donaldson