Clevidipine

Administration

  • Type: Calcium channel blockers, anti-hypertensive, dihydropyridine
  • Dosage Forms: 0.5 mg/mL (50 mL, 100 mL) emulsion
  • Routes of Administration: IV
  • Common Trade Names: Cleviprex

Adult Dosing

Hypertension

  • 1-2 mg IV per hour
    • Titration: Double dose at 90 second intervals toward blood pressure goal.
      • For every 1-2 mg/hour increase should see 2-4 mm Hg reduction

Special Populations

Pregnancy Rating

  • C

Lactation risk

  • Unknown

Renal Dosing

None

Hepatic Dosing

None

Contraindications

  • Allergy to class/drug
  • Allergy to soybeans, soy products, eggs, egg products
  • Severe aortic stenosis

Adverse Reactions

Serious

  • Atrial fibrillation
  • Renal failure
  • MI (<1%)
  • Intestinal obstruction (<1%)
  • Hypertriglyceridemia - similar to propofol, formulated with 20% fat emulsion, risk of developing pancreatitis

Common

  • Insomnia
  • Nausea
  • Fever
  • Headache

Pharmacology

  • Onset: 2-4 minutes
  • Half-life: 1 minute
  • Metabolism: hydrolysis by esterases in blood
  • Excretion: Urine (63-74%); feces (7 to 22%)

Mechanism of Action

Dihydropyridine CCB with arterial vasodilating activity. Inhibits calcium ion influx through L-type calcium channels. Decreases MAP and systemic vascular resistance.

Comments

  • $1.67 per mL (25 mg/50mL or 50 mg/100 mL)

See Also

References

Authors:

Matthew Rosen