Cilostazol

Administration

  • Type: Tab
  • Dosage Forms: 50 mg, 100 mg
  • Routes of Administration: Oral
  • Common Trade Names: Pletal

Adult Dosing

Intermittent claudication

  • 100 mg PO bid

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Pregnancy Rating

  • Caution advised during pregnancy
  • No risk of fetal harm, teratogenicity, or death
  • Increased risk of maternal bleeding during delivery

Lactation risk

  • Caution advised while breastfeeding

Renal Dosing

  • Adult: No adjustment
  • Pediatric: Unavailable

Hepatic Dosing

  • Adult: No adjustment
  • Pediatric: Unavailable

Contraindications

  • Allergy to class/drug
  • CHF
  • Hemostatic disorders
  • Active bleeding

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 11-13 hours; active metabolites
  • Metabolism: Liver; CYP450: 2C19, 3A4
  • Excretion: Urine 74%, feces 20%

Mechanism of Action

  • Inhibits phosphodiesterase type 3, reducing platelet aggregation
  • Suppresses cAMP degradation, producing vasodilation

Comments

See Also

References

Authors:

Jonathan Warren