Cefdinir

General

• Type: Third generation cephalosporin
• Dosage Forms: capsule, oral suspension
• Dosage Strengths: capsule: 300mg; oral suspension: 125mg/5mL, 250mg/5mL
• Routes of Administration: PO
• Common Trade Names: Omnicef

Adult Dosing

• 600mg/d divided q12-24hrs for 10 days for CAP, chronic bronchitis, acute sinusitis, strep pharyngitis, cellulitis

Pediatric Dosing

• 14mg/kg/d PO divided q12-24hrs x10 days, max of 600mg/day

Special Populations

• Pregnancy Rating: B
• Lactation: Probably safe
• Renal Dosing
  • Adult: CrCl <30, 300mg q24hrs; CrCl <10, 300mg q48hrs; supplement after HD
  • Pediatric: CrCl <30, 7mg/kg q24, max 300mg/dose; supplement after HD
• Hepatic dosing not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Common

• Stool discoloration which is guiac negative and returns to normal color after cessation

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

Antibiotic Sensitivities

Group	Organism	Sensitivity
Gram Positive	Strep. Group A, B, C, G	S
	Strep. Pneumoniae	S
	Viridans strep	S
	Strep. anginosus gp	X1
	Enterococcus faecalis	R
	Enterococcus faecium	X1
	MSSA	S
	MRSA	R
	CA-MRSA	R
	Staph. Epidermidis	I
	C. jeikeium	X1
	L. monocytogenes	R
Gram Negatives	N. gonorrhoeae	S
	N. meningitidis	X1
	Moraxella catarrhalis	S
	H. influenzae	S
	E. coli	S
	Klebsiella sp	S
	E. coli/Klebsiella ESBL+	R
	E coli/Klebsiella KPC+	R
	Enterobacter sp, AmpC neg	R
	Enterobacter sp, AmpC pos	R
	Serratia sp	R
	Serratia marcescens	X1
	Salmonella sp	S
	Shigella sp	S
	Proteus mirabilis	S
	Proteus vulgaris	I
	Providencia sp.	X1
	Morganella sp.	R
	Citrobacter freundii	R
	Citrobacter diversus	X1
	Citrobacter sp.	S
	Aeromonas sp	X1
	Acinetobacter sp.	X1
	Pseudomonas aeruginosa	R
	Burkholderia cepacia	X1
	Stenotrophomonas maltophilia	X1
	Yersinia enterocolitica	X1
	Francisella tularensis	X1
	Brucella sp.	X1
	Legionella sp.	R
	Pasteurella multocida	S
	Haemophilus ducreyi	X1
	Vibrio vulnificus	X1
Misc	Chlamydophila sp	X1
	Mycoplasm pneumoniae	X1
	Rickettsia sp	X1
	Mycobacterium avium	X1
Anaerobes	Actinomyces	X1
	Bacteroides fragilis	X1
	Prevotella melaninogenica	X1
	Clostridium difficile	X1
	Clostridium (not difficile)	X1
	Fusobacterium necrophorum	X1
	Peptostreptococcus sp.	X1

Key

• S susceptible/sensitive (usually)
• I intermediate (variably susceptible/resistant)
• R resistant (or not effective clinically)
• S+ synergistic with cell wall antibiotics
• U sensitive for UTI only (non systemic infection)
• X1 no data
• X2 active in vitro, but not used clinically
• X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
• X4 active in vitro, but not clinically effective for strep pneumonia

See Also

• Antibiotics (Main)