Burkholderia cepacia

Background

  • Infection occurs in patients who are immune suppressed or those with chronic lung disease (e.g. cystic fibrosis)
  • Often resistant to multiple antibiotics

Antibiotic Sensitivities[1]

Category Antibiotic Sensitivity
Penicillins Penicillin G R
Penicillin V R
Anti-Staphylocccal Penicillins Methicillin R
Nafcillin/Oxacillin R
Cloxacillin/Diclox. R
Amino-Penicillins AMP/Amox R
Amox-Clav R
AMP-Sulb R
Anti-Pseudomonal Penicillins Ticarcillin R
Ticar-Clav X1
Pip-Tazo X1
Piperacillin X1
Carbapenems Doripenem I
Ertapenem R
Imipenem R
Meropenem S
Aztreonam R
Fluroquinolones Ciprofloxacin R
Ofloxacin R
Pefloxacin X1
Levofloxacin X1
Moxifloxacin R
Gemifloxacin X1
Gatifloxacin R
1st G Cephalo Cefazolin R
2nd G. Cephalo Cefotetan R
Cefoxitin R
Cefuroxime R
3rd/4th G. Cephalo Cefotaxime I
Cefizoxime I
CefTRIAXone I
Ceftaroline R
CefTAZidime S
Cefepime I
Oral 1st G. Cephalo Cefadroxil R
Cephalexin R
Oral 2nd G. Cephalo Cefaclor/Loracarbef R
Cefproxil R
Cefuroxime axetil R
Oral 3rd G. Cephalo Cefixime R
Ceftibuten S
Cefpodox/Cefdinir/Cefditoren X1
Aminoglycosides Gentamicin R
Tobramycin R
Amikacin R
Chloramphenicol S
Clindamycin R
Macrolides Erythromycin R
Azithromycin R
Clarithromycin R
Ketolide Telithromycin R
Tetracyclines Doxycycline R
Minocycline I
Glycylcycline Tigecycline I
Daptomycin R
Glyco/Lipoclycopeptides Vancomycin R
Teicoplanin R
Telavancin R
Fusidic Acid R
Trimethoprim S
TMP-SMX S
Urinary Agents Nitrofurantoin R
Fosfomycin X1
Other Rifampin R
Metronidazole R
Quinupristin dalfoppristin X1
Linezolid R
Colistimethate R

Key

  • S susceptible/sensitive (usually)
  • I intermediate (variably susceptible/resistant)
  • R resistant (or not effective clinically)
  • S+ synergistic with cell wall antibiotics
  • U sensitive for UTI only (non systemic infection)
  • X1 no data
  • X2 active in vitro, but not used clinically
  • X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
  • X4 active in vitro, but not clinically effective for strep pneumonia

Table Overview

See Also

References

  1. Sanford Guide to Antimicrobial Therapy 2014