Fever of unknown origin (peds): Difference between revisions

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==See Also==
==See Also==
*[[Pediatric Fever]]
*[[Pediatric fever of uncertain source]]


==References==
==References==

Revision as of 06:00, 10 August 2015

Background

  • Prolonged fever of unknown origin without identified cause generally has favorable prognosis.

Clinical Features

  • Original definition[1]
    • Fever >38.3 C on several occasions
    • Lasting for at least 3 weeks
    • No clear diagnosis after 1 week inpatient workup
  • Newer definition[2] - "Prolonged fever" with:
    • 3 outpatient visits without identifying a cause or
    • 3 inpatient days without identifying a cause or
    • 1 week of “intelligent and invasive” ambulatory investigation

Differential Diagnosis

  • Infection
  • Non-infectious Inflammatory
  • Malignancy
    • Leukemia
    • Lymphoma
    • Neuroblastoma
    • Wilm's tumor
  • Drug Induced
    • Antibiotics
    • Anticonvulsants
    • Anti TB
    • Procainamide
    • Quinidine
    • Serum sickness
  • Misc

Diagnosis

  • Clinical (preliminary) diagnosis

Management

  • Treat underlying cause (once identified)
  • Empiric treatment generally not recommended

Disposition

  • Frequently admitted for workup

See Also

References

  1. ↑ Kaya A, Ergul N, Kaya SY, et al. The management and the diagnosis of fever of unknown origin. Expert Rev Anti Infect Ther. 2013 Aug;11(8):805-15.
  2. ↑ Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35-51.
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