Fever of unknown origin (peds): Difference between revisions

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{{Peds top}} [[fever of unknown origin]]
==Background==
==Background==
*Prolonged fever of unknown origin without identified cause generally has favorable prognosis.
*Prolonged fever of unknown origin without identified cause generally has favorable prognosis.
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***[[Sinusitis]]
***[[Sinusitis]]
***[[Tb]]
***[[Tb]]
***[[Mycoplasma|Mycoplasmal]]
***Chlamydial
****[[Lymphogranuloma venereum]]
****[[Psittacosis]]
***[[Rickettsia]]l
****[[Q fever]]
****[[Rocky mountain spotted fever]]
**Viral
**Viral
***CMV
***[[CMV]]
***Hep A,B, C
***[[Viral hepatitis]]
***Mono
***[[Mononucleosis]]
**Chlamydial
**[[Fungal infections|Fungal]]
***Lymphogranuloma venereum
***[[Blastomycosis]]
***Psittacosis
***[[Histoplasmosis]]
**Mycoplasmal
**[[Parasitic infection|Parasitic]]
**Fungal
***[[Malaria]]
***Blastomycosis
***[[Toxoplasmosis]]
***Cysticercosis
***[[Cysticercosis]]
***Histoplasmosis
***Rickettsial
****[[Q fever]]
****Rocky Mt
***Parasitic
****Malaria
****Toxo
*'''Non-infectious Inflammatory'''
*'''Non-infectious Inflammatory'''
**JRA
**[[Juvenile idiopathic arthritis]]
**LSE
**[[SLE]]
**Regional enteritis
**Regional enteritis
**Rheumatic fever
**[[Rheumatic fever]]
**[[Ulcerative colitis]]
**[[Ulcerative colitis]]
**Vasculitis
**[[Vasculitis]]
*'''Malignancy'''
*'''Malignancy'''
**Leukemia
**[[Leukemia]]
**Lymphoma
**[[Lymphoma]]
**Neuroblastoma
**[[Neuroblastoma (peds)|Neuroblastoma]]
**Wilm's tumor
**[[Wilms' tumor]]
*'''Drug Induced'''
*'''Drug Induced'''
**[[Antibiotics]]
**[[Antibiotics]]
**Anticonvulsants
**[[Anticonvulsants]]
**Anti TB
**Anti [[TB]]
**Procainamide
**[[Procainamide]]
**Quinidine
**[[Quinidine]]
**Serum sickness
**[[Serum sickness]]
*'''Misc'''
*'''Misc'''
**[[AIDS]]
**[[AIDS]]
**CNS
**CNS dysfunction
**Environmental
**Environmental [[hyperthermia]]
**Factitious
**Factitious
**Familial dysautonomia
**Familial dysautonomia

Latest revision as of 23:08, 28 November 2019

This page is for pediatric patients. For adult patients, see: fever of unknown origin

Background

  • Prolonged fever of unknown origin without identified cause generally has favorable prognosis.

Clinical Features

  • Original definition[1]
    • Fever >38.3 C on several occasions
    • Lasting for at least 3 weeks
    • No clear diagnosis after 1 week inpatient workup
  • Newer definition[2] - "Prolonged fever" with:
    • 3 outpatient visits without identifying a cause or
    • 3 inpatient days without identifying a cause or
    • 1 week of “intelligent and invasive” ambulatory investigation

Differential Diagnosis

Evaluation

  • Clinical (preliminary) diagnosis

Management

  • Treat underlying cause (once identified)
  • Empiric treatment generally not recommended

Disposition

  • Frequently admitted for workup

See Also

References

  1. ↑ Kaya A, Ergul N, Kaya SY, et al. The management and the diagnosis of fever of unknown origin. Expert Rev Anti Infect Ther. 2013 Aug;11(8):805-15.
  2. ↑ Durack DT, Street AC. Fever of unknown origin--reexamined and redefined. Curr Clin Top Infect Dis. 1991;11:35-51.
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