Quinine

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General

  • Type: Antimalarial
  • Dosage Forms: PO 324 (IM and IV formulations available outside US)
  • Common Trade Names: Qualaquin

Adult Dosing

Malaria

Babesiosis

Pediatric Dosing

Malaria

  • 30mg/kg/day PO q8h x 3-7 days
  • Max: 648mg/dose
  • See CDC Recommendations for full treatment recommendations

Babesiosis

  • 8mg/kg PO q8h x 7-10 days
  • Max: 648mg/dose
  • Use with Clindamycin

Special Populations

  • Pregnancy Rating: C
  • Lactation: Probably safe
  • Renal Dosing
    • Adult
      • Severe chronic renal failure: 648mg PO x 1 then 324mg PO q12h
      • If on HD give after dialysis
    • Pediatric
      • Not defined
  • Hepatic Dosing
    • Adult and Pediatric
      • No adjustment for Child-Pugh Class A or B
      • Avoid in Child-Pugh Class C

Contraindications

Black Box Warnings

  • Hematologic Toxicity with use for nocturnal leg cramps

General

Caution

Adverse Reactions

Serious

Common

  • Cinchonism
  • Headache
  • Vasodilation
  • Diaphoresis
  • Nausea/Vomiting
  • Tinnitus
  • Impaired hearing
  • Vertigo
  • Visual impairment
  • Fever
  • Flushing
  • asthenia
  • Rash
  • Pruritus
  • Urticaria
  • Diarrhea
  • Abdominal pain
  • Photosensitivity

Pharmacology

  • Half-life: 9-12 hours
  • Metabolism: Liver 80%, CYP450
  • Excretion: Urine
  • Mechanism of Action: Unknown

Administration

  • Give with food

See Also

References

  • Epocrates