Isoproterenol

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General

Adult Dosing

  • Loading dose: 0.02-0.06 mg IV, followed by infusion[1][2]
    • 2-20 mcg/min IV infusion
    • Titrate to HR and BP
  • Alternatively, bolus 0.02-0.06 mg IV, then 0.01-0.2 mg IV PRN

Pediatric Dosing

  • No well controlled studies for appropriate dosing
  • AHA recommends initial infusion of 0.1 mcg/kg/min, with titrated range usually 0.1-1 mcg/kg/min[3]

Special Populations

Indications

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Dramatic increase in O2 demand
  • V-tach (use lowest dose possible)

Pharmacology

  • Half-life: 2-10 min[4]
  • Metabolism: liver, CYP450
  • Excretion: urine primarily
  • Mechanism of Action: Beta adrenergic agonist

Kinetics

  • Onset of action = 1-5 min
  • Duration of action = 1-2 hr

Comments

See Also

References

  1. GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
  2. AthenaHealth. Epocrates. Isoproterenol - Entire Monograph. https://online.epocrates.com/u/10a106/isoproterenol.
  3. GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
  4. Hadwiger ME et al. Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling. J Pharm Biomed Anal. 1997 Feb;15(5):621-9.