Ipratropium

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General

  • Type: Anticholinergic Agent
  • Dosage Forms: Oral inhalation
  • Common Trade Names: Atrovent

Adult Dosing

Asthma: 0.5mg Nebulized q20min, up to 3 doses
COPD: 0.5mg Nebulized q20mins, up to 3 doses

Pediatric Dosing

Asthma

  • Children ≤5 years: 0.25mg Neb q20mins, up to 3 doses
  • Children ≤12 years: 0.25-0.5mg Neb q20mins, up to 3 doses
  • Children >12 years: Refer to adult dosing

Special Populations

Contraindications

  • Allergy to anticholenergics (Atropine, Ipatropium)
  • Not to be used as sole rescue agent in acute exacerbation

Adverse Reactions

Serious

  • Death

Common

  • Urinary retention
  • Increased intraocular pressure
  • Bitter taste in mouth
  • Dry throat/Cough
  • Nasal dryness

Pharmacology

  • Half-life: 2-5hrs
  • Metabolism: Possible ester hydrolysis
  • Excretion: Fecal and Renal
  • Mechanism of Action: Cholinergic antagonist of acetylcholine at the cholinergic receptors, causing dilatation of bronchial smooth muscle and decreased serous and seromucous glands secretion.

See Also

References