Ibuprofen

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General

  • Type: NSAID
  • Dosage Forms:
  • Common Trade Names: Advil; Motrin

Adult Dosing

  • 600mg PO Q6hours

Pediatric Dosing

  • 10mg/kg PO Q6hours
  • Max: 40mg/kg/day

Special Populations

  • Pregnancy Rating: C (1st-2nd trimester), D (3rd trimester)
  • Lactation risk categories: L4; enters breast milk, decreases milk supply
  • Renal Dosing
    • Adult: no adjustment
    • Pediatric: no adjustment
  • Hepatic Dosing
    • Adult: not defined
    • Pediatric: not defined

Contraindications

  • Allergy to class/drug
  • Cardiovascular
    • May cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal
    • Contraindicated for treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
  • Gastrointestinal risk
    • Increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal
      • Elderly patients are at greater risk for serious GI events.

Adverse Reactions

Serious

  • GI bleeding
  • ulceration and perforation of the stomach or intestines
  • thromboycytopenia
  • agranulocytosis
  • steven johnson syndrome
  • nephrotoxicity

Common

  • dyspepsia
  • nausea
  • abdominal pain
  • constipation
  • headache
  • dizziness
  • rash
  • fluid retention
  • ecchymosis

Pharmacology

  • Half-life: 1.8 - 2 hr
  • Metabolism: liver
  • Excretion: Urine
  • Mechanism of Action: exact mechanism unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

See Also

References