Hydrocortisone topical

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General

  • Type: Topical steroid
  • Dosage Forms: 0.5%, 1%, 2.5% crm, lotion, oint
  • Common Trade Names: Cortizone, Cortaid, Hytone, Texacort

Adult Dosing

Dermatoses, steroid-responsive

  • Apply bid-QID

Pediatric Dosing

Dermatoses, steroid-responsive

  • Apply bid-QID

Special Populations

  • Pregnancy Rating: C
  • Lactation: Excretion in milk unknown; use with caution
  • Renal Dosing: None
  • Hepatic Dosing: None

Contraindications

  • Allergy to class/drug
  • caution if skin infection
  • caution in pediatric patients

Adverse Reactions

Serious

  • HPA axis suppresion
  • Cushing syndrome
  • hyperglycemia
  • intracranial hypertension (pediatric patients)

Common

  • burning
  • pruritus
  • irritation
  • dryness
  • folliculitis
  • hypertrichosis
  • acneiform dermatitis
  • hypopigmentation
  • perioral dermatitis
  • allergic contact dermatitis
  • maceration
  • secondary infection
  • skin atrophy
  • striae
  • miliaria

Pharmacology

  • Half-life: 8-12h
  • Metabolism: liver primarily; CYP450
  • Excretion: urine
  • Mechanism of Action: exact mechanim of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple gluocorticoid and mineralocorticoid effects

See Also

References