Gemfibrozil
Administration
- Type: Antihyperlipidemic
- Dosage Forms: Tablet, 600mg
- Routes of Administration: oral
- Common Trade Names: Lopid
Adult Dosing
- 600mg PO BID 30m before meals
Pediatric Dosing
- Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: not recommended in severe renal impairment
- Hepatic dosing: contraindicated in hepatic dysfunction
Contraindications
- Allergy to class/drug
- Concomitant dasabuvir, repaglinide, or simvastatin
- Hepatic dysfunction, primary biliary cirrhosis, preexisting gallbladder disease
- Severe renal impairment
Adverse Reactions
Serious
- Increased LFTs
- Rhabdomyolysis
- Atrial Fibrillation
Common
- Abdominal pain, indigestion
- Appendicitis
- Fatigue, Vertigo
- Rash
Pharmacology
- Half-life: 1.5h
- Metabolism: Hepatic. Inhibitor of CYP2C8, OATP1B1, and OAT3, substrate of UGT2B7
- Excretion: Mostly renal
Mechanism of Action
- Stimulates peroxisome proliferator activated receptor alpha, which causes a decrease in triglyceride levels and an increase in high-density lipoprotein levels