Dopamine

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General

  • Type: Vasopressors
  • Dosage Forms: IV
  • Common Trade Names: Intropin

Adult Dosing

Dosing

  • Low dose:
    • 1-5 mcg/kg/min - Vasodilation (renal, mesenteric, coronary)
    • 5-10 mcg/kg/min - predominant β1
  • High dose: 10-20 mcg/kg/min - predominant α1
  • Titrate to clinical effect
    • Use lowest dose possible (prevent tachyphylaxis)
  • May use in peripheral IV temporarily
    • Avoid using in same line as alkaline infusions

Rate of Titration

  • Q2-5 min

Pediatric Dosing

Special Populations

  • Pregnancy Rating: Class C
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug
  • Tachyarrhythmias

Adverse Reactions

  • Low doses:
    • Hypotension
  • High doses:
    • Hypertension, ectopic beats
  • Tissue necrosis (if extravasates)
    • If occurs use phentolamine 5-10mg in affected area

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

Primary Receptor

  • Low dose: DA, β1
  • High dose: DA, α1 >> β1

Relative Effects

  • Low dose: Natriuresis, ↑↑HR, ↑↑SV
  • High dose: ↑SVR and ↑SV

Notes

Indications

  • Hypotension caused by:
    • Septic shock
    • MI
    • Trauma/spinal shock
    • Heart failure

See Also

References