Isoproterenol: Difference between revisions
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==General== | ==General== | ||
*Type: Beta agonist; [[Antiarrhythmics]] | *Type: Beta agonist; [[Antiarrhythmics]] | ||
*Dosage Forms: | *Dosage Forms: IV or IM injection | ||
*Common Trade Names: | *Common Trade Names: Isoprenaline, Isuprel | ||
==Adult Dosing== | ==Adult Dosing== | ||
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**2-20 mcg/min IV infusion | **2-20 mcg/min IV infusion | ||
**Titrate to HR and BP | **Titrate to HR and BP | ||
*Alternatively, bolus 0.02-0.06 mg IV, then 0.01-0.2 mg IV PRN | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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==Indications== | ==Indications== | ||
*Refractory torsades | *Refractory [[torsades]] | ||
*Refractory symptomatic bradycardia | *Refractory symptomatic [[bradycardia]] | ||
*Refractory [[electrical storm]] | |||
*[[Brugada syndrome]] | |||
==Contraindications== | ==Contraindications== | ||
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 2-10 min<ref>Hadwiger ME et al. Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling. J Pharm Biomed Anal. 1997 Feb;15(5):621-9.</ref> | ||
*Metabolism: | *Metabolism: liver, CYP450 | ||
*Excretion: | *Excretion: urine primarily | ||
*Mechanism of Action: | *Mechanism of Action: Beta adrenergic agonist | ||
===Kinetics=== | ===Kinetics=== | ||
*Onset of action = 1- | *Onset of action = 1-5 min | ||
*Duration of action = 1- | *Duration of action = 1-2 hr | ||
==Comments== | ==Comments== | ||
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<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:Cardiology]] | |||
Latest revision as of 19:17, 29 December 2023
General
- Type: Beta agonist; Antiarrhythmics
- Dosage Forms: IV or IM injection
- Common Trade Names: Isoprenaline, Isuprel
Adult Dosing
- Loading dose: 0.02-0.06 mg IV, followed by infusion[1][2]
- 2-20 mcg/min IV infusion
- Titrate to HR and BP
- Alternatively, bolus 0.02-0.06 mg IV, then 0.01-0.2 mg IV PRN
Pediatric Dosing
- No well controlled studies for appropriate dosing
- AHA recommends initial infusion of 0.1 mcg/kg/min, with titrated range usually 0.1-1 mcg/kg/min[3]
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unknown
- Renal Dosing - undefined
- Hepatic Dosing - undefined
Indications
- Refractory torsades
- Refractory symptomatic bradycardia
- Refractory electrical storm
- Brugada syndrome
Contraindications
- Allergy to class/drug
Adverse Reactions
- Dramatic increase in O2 demand
- V-tach (use lowest dose possible)
Pharmacology
- Half-life: 2-10 min[4]
- Metabolism: liver, CYP450
- Excretion: urine primarily
- Mechanism of Action: Beta adrenergic agonist
Kinetics
- Onset of action = 1-5 min
- Duration of action = 1-2 hr
Comments
See Also
References
- ↑ GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
- ↑ AthenaHealth. Epocrates. Isoproterenol - Entire Monograph. https://online.epocrates.com/u/10a106/isoproterenol.
- ↑ GlobalRPH. Isoproterenol Dilution. http://www.globalrph.com/isoproterenol_dilution.htm.
- ↑ Hadwiger ME et al. Simultaneous determination of the elimination profiles of the individual enantiomers of racemic isoproterenol using capillary electrophoresis and microdialysis sampling. J Pharm Biomed Anal. 1997 Feb;15(5):621-9.