Trazodone toxicity

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Background

  • Trazodone is extremely safe in overdose as long as there are no coingestants
  • Has serotonergic and α blocking effects

Clinical Features

  • CNS depression
    • Most common symptom
    • Rarely produces coma or seizures when it is the only drug ingested
  • Respiratory depresion
    • Fairly common (but only with coingestants)
  • Orthostatic hypotension
  • QT prolongation

Differential Diagnosis

Evaluation

Management

Disposition

  • Consider discharge for patients who remain asymptomatic for at least 6 hours

See Also

References