Lomotil toxicity

Background

  • Mixture of diphenoxylate/atropine used to treat diarrhea
  • Children are especially sensitive to toxicity (death reported after ingestion of <5 tablets)

Mechanism of toxicity

Clinical Features

Differential Diagnosis

Sedative/hypnotic toxicity

Anticholinergic toxicity Causes

Evaluation

  • Diagnosis is based on history and signs of toxicity

Management

Disposition

  • Pediatric patients should be observed in the ICU for 24 hours given risk of sudden respiratory arrest

See Also

References

  • Olson, K. Poisoning and Drug Overdose Clinical Manual. 2004