Trazodone

Administration

  • Type: Antidepressant
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names:

Adult Dosing

  • Insomnia: 50-100mg PO at bedtime
  • Depression: 150-600 mg/day in divided doses

Pediatric Dosing

Safety/efficacy not established

Special Populations

Contraindications

  • Allergy to class/drug
  • MAOI use currently or in past 2 weeks
  • Concomitant use of saquinavir/ritonavir

Adverse Reactions

Serious

  • Prolonged QT, Torsades de pointes
  • Hypotension
  • Serotonin syndrome
  • Suicidal thoughts/behavior
  • Seizure
  • Priapism

Common

  • Somnolence, dizziness, confusion, insomnia, anxiety, dream disorder
  • Headache, blurred vision
  • Constipation, nausea/vomiting, xerostomia
  • Backache

Pharmacology

  • Half-life: 7h
  • Metabolism: Hepatic, CYP3A4
  • Excretion: Mostly renal

Mechanism of Action

  • Not well understood. May act like a SSRI. Also an α-1 adrenergic antagonist

Comments

See Also

References

Authors:

Claire, Neil Young