Ticlopidine

Administration

  • Type: Antiplatelet
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names: Ticlid

Adult Dosing

  • 250mg PO BID

Pediatric Dosing

Safety/efficacy not established

Special Populations

Contraindications

  • Allergy to class/drug
  • Hematopoietic disorders (e.g. neutropenia, thrombocytopenia, or past history of TTP or aplastic anemia)
  • Active bleeding
  • Severe liver disease

Adverse Reactions

Serious

  • Aplastic anemia, pancytopenia, agranulocytosis, pancytopenia, thrombocytopenia, neutorpenia, TTP

Common

  • Rash
  • Nausea, diarrhea, abdominal pain
  • Hemorrhage
  • Leukopenia
  • Dizziness

Pharmacology

  • Half-life: 4-5 days
  • Metabolism: Hepatic
  • Excretion: Mostly renal

Mechanism of Action

  • Prevents ADP from stimulating platelet-fibrinogen binding, blocking platelet aggregation

Comments

See Also

References

Authors:

Claire