Strychnine

Background

  • Strychnine is a highly toxic substance, mimics generalized tetanus
  • Antagonizes glycine release, but unlike TS, it has no effect on GABA release

Clinical Features

Differential Diagnosis

  • Generalized tetanus
  • Black widow spider bite
  • Stiff-man syndrome

Jaw Spasms

Evaluation

  • Serum and urine tests for strychnine

Management

Disposition

  • All patients should be admitted

See Also

References