Mesalamine

Administration

  • Type: Anti-inflammatory
  • Dosage Forms: TAB 800mg, 1.2g
  • Routes of Administration: Oral
  • Common Trade Names: Apriso, Asacol, Asacol HD, Delzicol, Lialda, Pentasa

Adult Dosing

Ulcerative Colitis

  • Mild-Moderate Active
    • 2.4-4.8g PO qd x 8 weeks
  • Moderate Active
    • 1600 mg PO tid x 6 weeks
  • Maintenance tx
    • 2.4 g PO qd

Pediatric Dosing

  • Chron Disease
    • 50-100mg/kg/day PO divided every 6-12hrs; max dose 1000mg/dose
  • Ulcerative Colitis (mild to moderate)
    • Children >5 years old:
      • 17 to <33 kg: Oral: 800 mg in the morning and 400 mg in the evening for 6 weeks; maximum daily dose: 1,200 mg/day
      • 33 to <54 kg: Oral: 1,200 mg in the morning and 800 mg in the evening for 6 weeks; maximum daily dose: 2,000 mg/day
      • 54 to 90 kg: Oral: 1,200 mg in the morning and 1,200 mg in the evening for 6 weeks; maximum daily dose: 2,400 mg/day

Special Populations

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug
  • Influenza, varicella, or febrile infection in pts <20 yo

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2-15h (tid dosing) and 7-12h (qd dosing)
  • Metabolism: GI tract, liver
  • Excretion: Urine, feces

Mechanism of Action

  • Blocks cyclooxygenase and inhibits prostaglandin production in the colon, exerting local anti-inflammatory effects

Comments

See Also

References

Authors:

Jonathan Warren