Ketoprofen

Administration

  • Type: NSAID
  • Dosage Forms: Cap 50mg, 75mg; ER Cap 200mg
  • Routes of Administration: Oral
  • Common Trade Names:

Adult Dosing

Pain, mild-moderate

  • 50mg PO q6-8h
    • Max: 300mg/day

Osteoarthritis

  • 75mg PO TID or 50mg PO qid or 200mg ER PO daily
    • Max: 300mg/day

Rheumatoid arthritis

  • 75mg PO TID or 50mg PO qid or 200mg ER PO daily
    • Max: 300mg/day

Dysmenorrhea

  • 50mg PO q6-8h
    • Max: 300mg/day

Anti-inflammatory uses

  • 50-100mg PO TID x7-14 days
    • Max: 300mg/day

Pediatric Dosing

  • Pediatric safety for this drug has not yet been established

Special Populations

Pregnancy Rating

  • Caution advised in 1st trimester for risk of embryo-fetal toxicity
  • Avoid use starting at 30 wk gestation for risk of premature fetal ductus arteriosus closure
  • Caution advised in female pts trying to conceive

Lactation risk

  • Consider alternative while breastfeeding

Renal Dosing

  • Adult:
    • Mild Impairment: Max 150 mg/day
    • CrCl <25: Max 100 mg/day
    • HD/PD: No supplement
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Max 100 mg/day with hepatic impairment
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug
  • ASA or NSAID-induced asthma or urticaria
  • Pregnancy starting at 30wk gestation
  • CABG surgery periop use
  • Aspirin triad

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2.1h
  • Metabolism: Liver extensively, tissues
  • Excretion: Urine 80% (<10% unchanged)

Mechanism of Action

  • Inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

Comments

See Also

References

Authors:

Jonathan Warren