Ivermectin

General

  • Type: antiparasitic
  • Dosage Forms: 3
  • Common Trade Names: Stromectol

Adult Dosing

Strongyloidiasis

  • 0.2mg/kg PO x1

Onchocerciasis

  • 0.15mg/kg PO x1

Scabies, non-crusted

  • 0.2mg/kg PO x1

Scabies, crusted

  • 0.2mg/kg PO x1 on days 1,2,8,9,15

Pediculosis capitis

  • 0.2mg/kg pO q10 days x2 doses

Pediculosis corporis

  • 12mg PO q7 days x3 doses

Pediculosis pubis

  • 0.25mg/kg PO q2wk x2 doses

Pediatric Dosing

Special Populations

  • Pregnancy Rating: C
  • Lactation: Safety Unknown
  • Renal Dosing- not defined
  • Hepatic Dosing- not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

  • pruritus
  • rash
  • fever
  • edema
  • lymphadenopathy
  • headache
  • myalgia
  • dizziness
  • tachycardia
  • abnormal eye sensation
  • limbitis
  • conjunctivitis
  • ocular inflammation
  • hypotension, orthostatic
  • ALT, AST elevated
  • eosinophilia

Pharmacology

  • Half-life: 18h
  • Metabolism: liver, CYP450: unknown
  • Excretion: feces primarily, urine < 1%
  • Mechanism of Action: increases invertebrate nerve and muscle cell membrane permeability by binding to chloride ion channels, resulting in paralysis and death of parasite

See Also

References