Grey baby syndrome

Background

  • A side effect of chloramphenicol affecting newborns of mothers who have been exposed to the drug
  • Thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion

Clinical Features

  • Symptoms usually occur within 1 week of exposure and include:
    • Ashen gray color of the skin
    • Failure to thrive
    • Poor appetite
    • Vomiting
    • Hypotension
    • Hypothermia

Differential Diagnosis

Evaluation

Management

Disposition

See Also

External Links

References