Glyburide

Administration

• Type: Sulfonylurea
• Dosage Forms: Tab: 1.25mg, 2.5 mg, 5 mg
• Routes of Administration: Oral
• Common Trade Names: DiaBeta, Micronase

Adult Dosing

Diabetes mellitus, Type 2

• 1.25-20 mg/day PO divided qd-bid
  • Max: 20mg/day

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

• Pregnancy Rating: C
• Lactation risk: Caution advised while breastfeding

Renal Dosing

• Adult:
  • CrCl <50: Avoid Use
• Pediatric:
  • No current guidelines

Hepatic Dosing

• Adult:
  • Start at 1.25 mg qd
• Pediatric:
  • No current guidelines

Contraindications

• Allergy to class/drug
• CrCl < 50
• DKA
• Diabetes mellitus, type 1

Adverse Reactions

Serious

• Exfoliative dermatitis
• Erythema multiforme
• Hypoglycemia
• Cholestatic jaundice
• Hepatitis
• Aplasic anemia, hemolytic anemia, pancytopenia, thrombocytopenia
• Hyponatremia, SIADH
• Disulfiram-like rxn

Common

• Nausea, Dyspepsia
• Blurred vision
• Weight gain
• Drowsiness
• Rash

Pharmacology

• Half-life: 10h
• Metabolism: Liver; CYP2C9 substrate
• Excretion: Bile 50%, Urine 50%

Mechanism of Action

• Stimulates pancreatic islet beta cell insulin release

See Also

Diabetes Medications