Dexamethasone

General

Adult Dosing

Anaphylaxis

  • 10mg IV or PO

Pediatric Dosing

Anaphylaxis

  • 0.6mg/kg

Asthma Exacerbation

  • 0.6mg/kg once PO

Post-operative Airway Edema

  • 0.5 mg/kg PO q6hrs x1-2 days

Special Populations

  • Pregnancy Rating: C
  • Lactation: Single doses are considered compatible however corticosteroids are present in breast milk and further discussion should be had with mother due to potential serious adverse reactions in breastfed infant.
  • Renal Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined
  • Hepatic Dosing
    • Adult
      • Not defined
    • Pediatric
      • Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
    • Adults: Oral 4 ± 0.9 hours, IV 1 - 5 hours
  • Metabolism: Hepatic
  • Excretion: Urine ~10%
  • Mechanism of Action: surpasses neutrophil migration, decreases production of inflammatory mediators, reverses increased capillary permeability, suppresses normal immune response

See Also

References


Dexamethasone (systemic): Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.