Minocycline: Difference between revisions
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==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Avoided in children < 8 d/t calcium deposition in teeth | |||
*Children >8 years: PO, IV: 4 mg/kg/dose for 1 dose; Then 2 mg/kg/dose every 12 hours | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D | ||
*Lactation: | *Lactation: | ||
*Renal Dosing | *Renal Dosing | ||
Line 26: | Line 28: | ||
===Common=== | ===Common=== | ||
==Pharmacology== | ==Pharmacology== | ||
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==See Also== | ==See Also== | ||
== | ==References== | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] |
Latest revision as of 23:31, 22 September 2019
General
- Type: tetracycline
- Dosage Forms: IV, PO
- Common Trade Names:
Adult Dosing
- IV or PO: 200 mg initial dose, then 100 mg q12h.
Pediatric Dosing
- Avoided in children < 8 d/t calcium deposition in teeth
- Children >8 years: PO, IV: 4 mg/kg/dose for 1 dose; Then 2 mg/kg/dose every 12 hours
Special Populations
- Pregnancy Rating: D
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
References
- ↑ Sanford Guide to Antimicrobial Therapy 2014