Ivermectin: Difference between revisions
Line 35: | Line 35: | ||
*tachycardia | *tachycardia | ||
*seizures | *seizures | ||
*Stevens-Johnson syndrome | *[[Stevens-Johnson syndrome]] | ||
*toxic epidermal necrolysis | *[[toxic epidermal necrolysis]] | ||
*asthma exacerbation | *[[asthma]] exacerbation | ||
*vision loss | *vision loss | ||
*conjunctival hemorrhage | *[[conjunctival hemorrhage]] | ||
*hepatitis | *[[hepatitis]] | ||
===Common=== | ===Common=== | ||
*pruritus | *pruritus | ||
*rash | *[[rash]] | ||
*fever | *[[fever]] | ||
*edema | *edema | ||
*lymphadenopathy | *lymphadenopathy | ||
*headache | *[[headache]] | ||
*myalgia | *myalgia | ||
*dizziness | *[[dizziness]] | ||
*tachycardia | *tachycardia | ||
*abnormal eye sensation | *abnormal eye sensation | ||
*limbitis | *limbitis | ||
*conjunctivitis | *[[conjunctivitis]] | ||
*ocular inflammation | *ocular inflammation | ||
*hypotension, orthostatic | *hypotension, orthostatic |
Revision as of 21:29, 3 August 2015
General
- Type: antiparasitic
- Dosage Forms: 3
- Common Trade Names: Stromectol
Adult Dosing
strongyloidiasis: 0.2 mg/kg PO x1
onchocerciasis: 0.15 mg/kg PO x1
scabies, non-crusted: 0.2 mg/kg PO x1
scabies, crusted: 0.2 mg/kg PO x1 on days 1,2,8,9,15
pediculosis capitis: 0.2 mg/kg pO q10 days x2 doses
pediculosis corporis: 12 mg PO q7 days x3 doses
pediculosis pubis: 0.25 mg/kg PO q2wk x2 doses
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Safety Unknown
- Renal Dosing- not defined
- Hepatic Dosing- not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- hypotension, orthostatic
- tachycardia
- seizures
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- asthma exacerbation
- vision loss
- conjunctival hemorrhage
- hepatitis
Common
- pruritus
- rash
- fever
- edema
- lymphadenopathy
- headache
- myalgia
- dizziness
- tachycardia
- abnormal eye sensation
- limbitis
- conjunctivitis
- ocular inflammation
- hypotension, orthostatic
- ALT, AST elevated
- eosinophilia
Pharmacology
- Half-life: 18h
- Metabolism: liver, CYP450: unknown
- Excretion: feces primarily, urine < 1%
- Mechanism of Action: increases invertebrate nerve and muscle cell membrane permeability by binding to chloride ion channels, resulting in paralysis and death of parasite