Clarithromycin: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: macrolide | ||
*Dosage Forms: | *Dosage Forms: 250, 500, 500ER; 125, 250/5ml | ||
*Common Trade Names: Biaxin | *Common Trade Names: Biaxin, Biaxin XL | ||
==Adult Dosing== | ==Adult Dosing== |
Revision as of 01:09, 3 September 2015
General
- Type: macrolide
- Dosage Forms: 250, 500, 500ER; 125, 250/5ml
- Common Trade Names: Biaxin, Biaxin XL
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Liver disease
- Renal disease
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 3-4 hours (increased with dosage increase)[1]
- Metabolism: hepatic (rapid first-pass metabolism)
- Excretion: renal
- Mechanism of Action: interferes with bacterial protein synthesis by binding to a component of the 50S subunit
Antibiotic Sensitivities[2]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia