Antidotes
TOXIN | ANTIDOTE |
Acetaminophen |
|
Anticholinergics | Physostigmine |
Arsenic | Dimercaprol (BAL) |
Benzodiazepines |
|
Beta blockers |
Adult: 3-10mg IV Peds: 50-150mcg/kg IV |
Calcium chloride 10% Adult: 10 mL IV Peds: 0.2-0.25 mL/kg IV High Dose Insulin (1 unit/kg/hr) | |
Adult: 0.4-2mg IV Peds: 0.1mg/kg IV (max 2mg) | |
Cyanide |
Hydroxycobalamin OR Cyanide Antidote Kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) |
Digoxin | Dig Immune Fab |
Ethylene glycol |
Fomepizole 15mg/kg IV; then 10mg/kg q12h |
Fluoride | Calcium Gluconate |
Heparin |
Protamine Sulfate Adult: 25-50mg IV (empiric dose) over 10 minutes Peds: 0.6mg/kg IV (empiric dose) Note: Rapid protamine infusion causes hypotension[1] |
Iron | Deferoxamine |
Isoniazid (INH) |
Pyridoxine (Vit B6) Adult: 5gm IV Peds: 1gm/kg regardless of age [2] |
Lead | EDTA, succimer |
Mercury | Dimercaprol (BAL) |
Methanol | Fomepizole
15mi/kg IV; then 10mg/kg q12h |
Methemoglobinemia | Methylene blue |
Opiods | Naloxone |
Organophosphates | Atropine + Pralidoxime |
Sulfonylurea |
Octreotide Adult: 50–100mcg SC q6hr Peds: 1mcg/kg SC q6hr |
Tricyclic (TCA) Toxicity |
Bicarbonate 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion |
Valproate | L-Carnitine |
Warfarin | Vitamin K, FFP, Prothrombin Complex Concentrates |
Source
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