Calcium chloride

See critical care quick reference for drug doses by weight.


  • Type: Mineral, Antidote
  • Dosage Forms: injectable solution
  • Dosage Strengths: 100 mg/mL
  • Routes of Administration: IV
  • Common Trade Names:

Adult Dosing

Pediatric Dosing

See critical care quick reference for drug doses by weight.

Special Populations

  • Pregnancy Rating: C
  • Lactation: Infant risk cannot be ruled out
  • Renal Dosing: base dosing on serum Ca if CrCl <25, may need reduced dose if on HD
  • Hepatic dosing: No adjustment


  • Allergy to class/drug
  • Current use of ceftriaxone sodium injection in neonates
  • Ventricular fibrillation
  • Do NOT administer for IM or subq
  • Administer through central venous access except in cases of cardiac arrest
    • High risk of extravasation and tissue necrosis

Adverse Reactions


  • Vasodilation
  • Tissue necrosis (if extravasated)


  • Burning sensation


  • Half-life:
  • Metabolism:
  • Excretion: Renal, fecal

Mechanism of Action

  • Cofoactor in many enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways

See Also


  1. Neumar RW, Otto CW, Link MS, et al. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2010;122(18 Suppl 3):729-767. doi: 10.1161/CIRCULATIONAHA.110.970988. [PubMed 20956224]