Fresh frozen plasma

(Redirected from Fresh Frozen Plasma)



  • Rapid reversal of warfarin anticoagulation (in setting of bleeding or need for invasive procedure)
  • Bleeding and multiple coagulation defects (e.g. DIC with significant PT/PTT elevation)
  • Correction of coagulation defects for which no specific factor is available
  • Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy

Adult Dosing

  • 1 bag = 1 unit = 250 mL
  • 10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30%
  • Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)
  • Must be thawed in 37 degree Celsius water bath for about 45 minutes prior to administration[1]

Pediatric Dosing

  • Neonates/small children: 10-20 mL/kg will increase factor levels by 15-25%

Special Populations


  • Allergy to class/drug
  • ABO incompatibility

Adverse Reactions



  • Headache, paresthesia
  • Nausea
  • Pruritus, urticaria


  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:


  • Contains all coagulation factors and fibrinogen
    • 40 mL/kg raises any factor by 100% (each unit is ~200mL)
  • May cause fluid overload
  • ABO compatibility a must but crossmatch before transfusing not
  • INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised[2]
  • Retains active coagulation factors for up to 5 days after being thawed

See Also


  1. Westphal RG, Tindle B, Howard PL, Golden EA, Page GA. Rapid thawing of fresh frozen plasma. Am J Clin Pathol. 1982;78(2):220-222. doi:10.1093/ajcp/78.2.220
  2. Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9.