Amoxicillin/Clavulanate: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: Antibiotic | ||
*Dosage Forms: | *Dosage Forms: PO | ||
*Common Trade Names: Augmentin | *Common Trade Names: Augmentin | ||
==Adult Dosing== | ==Adult Dosing== | ||
Infection, Bacterial: | |||
* 500 mg-875 mg PO q12h | |||
Pneumonia, community-acquired | |||
*2000 mg ER PO q12h x 7-10 days | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Infection, Bacterial: | |||
* 25-45 mg/kg PO divided q12h | |||
Otitis Media: | |||
* 90 mg/kg/day PO divided q12h x 10 days | |||
==Special Populations== | ==Special Populations== | ||
*Pregnancy: | *Pregnancy: B | ||
*Lactation: | *Lactation: probably safe | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult: CrCl 10-30: give q12h, CrCl < 10, give q24h | ||
**Pediatric | **Pediatric: CrCl 10-30: give q12h, CrCl < 10, give q24h | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult: none | ||
**Pediatric | **Pediatric: none | ||
==Contraindications== | ==Contraindications== | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* anaphylaxis | |||
*steven johnson syndrome | |||
* c.diff associated diarrhea | |||
*hemolytic anemia | |||
*leukopenia | |||
* thrombocytopenia | |||
* hepatitis | |||
*seizures | |||
===Common=== | ===Common=== | ||
*diarrhea | |||
*nausea | |||
*rash | |||
*pruritus | |||
*vomiting | |||
*glossitis | |||
* transaminitis | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 1.1 hour | ||
*Metabolism: | *Metabolism: Liver | ||
*Excretion: | *Excretion: urine | ||
*Mechanism of Action: | *Mechanism of Action:Bactericidal, inhibits cell wall mucopeptide synthesis, inhibits beta lactamases | ||
==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>== | ==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>== |
Revision as of 21:35, 11 October 2015
General
- Type: Antibiotic
- Dosage Forms: PO
- Common Trade Names: Augmentin
Adult Dosing
Infection, Bacterial:
- 500 mg-875 mg PO q12h
Pneumonia, community-acquired
- 2000 mg ER PO q12h x 7-10 days
Pediatric Dosing
Infection, Bacterial:
- 25-45 mg/kg PO divided q12h
Otitis Media:
- 90 mg/kg/day PO divided q12h x 10 days
Special Populations
- Pregnancy: B
- Lactation: probably safe
- Renal Dosing
- Adult: CrCl 10-30: give q12h, CrCl < 10, give q24h
- Pediatric: CrCl 10-30: give q12h, CrCl < 10, give q24h
- Hepatic Dosing
- Adult: none
- Pediatric: none
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- steven johnson syndrome
- c.diff associated diarrhea
- hemolytic anemia
- leukopenia
- thrombocytopenia
- hepatitis
- seizures
Common
- diarrhea
- nausea
- rash
- pruritus
- vomiting
- glossitis
- transaminitis
Pharmacology
- Half-life: 1.1 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:Bactericidal, inhibits cell wall mucopeptide synthesis, inhibits beta lactamases
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
Source
- ↑ Sanford Guide to Antimicrobial Therapy 2014