Dapsone

Administration

• Type: Antibiotic
• Dosage Forms: 25,100
• Routes of Administration: Oral

Adult Dosing

Hansen's disease (leprosy)

• paucibacillary: 100mg PO QD x6mo
  • Use with rifampin
• multibacillary: 100mg PO QD x12mo
  • Use with rifampin, clofazimine

Bullous pemphigoid

• 50mg PO QD
  • Use with topical or systemic corticosteroids

Dermatitis herpetiformis

• 50mg PO QD

PCP

• Prophylaxis: 100mg/day PO divided QD-bid
  • Off label use
• Treatment: 100mg PO QD x21 days
  • Not 1st-line agent; use with trimethoprim
  • Off label use

Malaria suppression

• 100mg PO qwk
  • Use with pyrimethamine
  • Off label use

Toxoplasmosis prophylaxis

• 50mg PO QD
  • Off label use

Indications by Disease

Disease	Dose	Context
Bullous pemphigoid	50mg PO QD; Use with topical or systemic corticosteroids	Bullous pemphigoid
Dermatitis herpetiformis	50mg PO QD	Dermatitis herpetiformis
Leprosy	paucibacillary: 100mg PO QD x6mo; Use with rifampin; multibacillary: 100mg PO QD x12mo; Use with rifampin, clofazimine	Hansen's disease (leprosy)
Malaria	100mg PO weekly	Suppression
Pneumocystis jirovecii pneumonia	100mg PO once daily	Mild disease with TMP
Toxoplasmosis	50mg PO QD; Off label use	Toxoplasmosis prophylaxis

Pediatric Dosing

Indications by Disease

Disease	Dose	Context
Pneumocystis jirovecii pneumonia	2mg/kg/day PO (max 100mg)	Pediatric Mild
Pneumocystis jirovecii pneumonia	2mg/kg/day PO daily (max 100mg)	Pediatric Prophylaxis alt

Special Populations

• Pregnancy Rating: C
• Lactation risk: Probably unsafe

Renal Dosing

• No adjustment

Hepatic Dosing

• Caution advised with hepatic impairment
• CBC qwk x4, qmo x6, then q6mo thereafter
• LFTs at baseline, then periodically

Contraindications

• Allergy to class/drug
• caution if renal or hepatic impairment
• caution if impaired cardiovascular function

Adverse Reactions

Serious

• anemia, hemolytic
• aplastic anemia
• agranulocytosis
• exfoliative dermatitis
• erythema multiforme
• toxic epidermal necrolysis

Common

• fever
• myalgia
• headache
• rigors
• fatigue
• malaise
• dizziness

Pharmacology

• Half-life: 28 hrs
• Metabolism: Liver, CYP450
• Excretion: Urine