Opsoclonus
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Background
Opsoclonus is involuntary, irregular multidirectional saccadic eye movements. It occurs at fixed gaze and has been reported with ingestion of many medication overdoses such as organophosphates, lithium, cetirizine, amitryptiline, and diphenhydramine.[1]
Clinical Features
- Multidirectional eye movements when at fixed gaze
Differential Diagnosis
Neurologic Causes
Toxicologic
- Alcohol intoxication
- Amphetamines
- Barbiturates
- Benzodiazepines
- Ketamine
- Lithium toxicity
- Other anticonvulsants or sedatives
- Phencyclidine (PCP)
- Phenytoin (Dilantin)
- Salicylates
- SSRI toxicity
- Thiamine deficiency
Evaluation
Management
Disposition
See Also
External Links
References
- ↑ Carstairs S. et al. Opsoclonus Due to Diphenhydramine Poisoning. N Engl J Med 2010; 363:e40