Thiamine

Administration

  • Dosage Forms: 50,100,250,500mg
  • Routes of Administration: IM, IV
    • Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
  • Common Trade Names: Vitamin B1

Adult Dosing

  • Beriberi
    • 10-20mg IM tid x 2wk
      • Then 5-30mg PO QD x1mo
  • Wet beriberi with CHF
    • 10-30mg IV tid
  • Wernicke encephalopathy
    • 100mg IV x1
      • Then 50-100mg IM/IV QD

Pediatric Dosing

Special Populations

Renal Dosing

Not defined

Hepatic Dosing

Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • anaphylaxis
  • angioedema
  • cyanosis

Common

  • injection site pain
  • pruritus
  • warmth sensation
  • urticaria

Pharmacology

  • Half-life: Unknown
  • Metabolism: Liver, CYP450, Unknown
  • Excretion: Urine

Mechanism of Action

Physiologic cofactor

Comments

See Also

Thiamine deficiency

References